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Rat IL-17AF Heterodimer

Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines.  IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation.  IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses.

SKU Select size Price Buy
300-29-5ug Mini: 5 ug $67.00 + -
300-29-25ug Std.: 25 ug $168.00 + -
300-29-100ug Value: 100 ug $646.00 + -
300-29-500ug Midgi: 500 ug $3,209.00 + -
300-29-1mg Mg: 1 $5,347.00 + -

Accession Number: Q61453/Q5BJ95
Description:  Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines.  IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation.  IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses.  IL-17AF induces chemokine and airway neutrophilia production, similar in function to IL-17A and IL-17F homodimers.  In regard to these functions, IL-17AF is less active than the IL-17A homodimer and shows greater activity than the IL-17F homodimer.  Human and rat IL-17AF are active on mouse cells. 
Source:  Genetically modified E.coli.
Predicted MW: Dimer, 30.2 kDa ((IL-17A=134; IL-17F=135; Total=269 amino acids) aa)
AA Sequence:  IL-17A: MAVLIPQSSV CPNAEANNFL QNVKVNLKVL NSLSSKASSR RPSDYLNRST SPWTLSRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPEKCPF TFRVEKMLVG VGCTCVSSIV RHAS IL-17F:MARRNPKVGL SALQKAGNCP PLEDNSVRVD IRIFNQNQGI SVPRDFQNRS SSPWD YNITR DPDRFPSEIA EAQCRHSGCI NAQGQEDGSM NSVPIQQEIL VLRREPQGCS NSFRLEKMLI KVGCTCVTPI VHHAA
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

No biological activity data is available at this time

No biological activity data is available at this time 

 
Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

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Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0709 Lot 0709
SDS    

 

 

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