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Mouse TPO

Thrombopoietin (TPO) is a growth factor that is produced by liver and kidney tissues. TPO binds the TPO receptor (CD110) to promote megakaryocyte maturation, differentiation, and the production of platelets.

SKU Select size Price Buy
200-32-2ug Mini: 2 ug $67.00 + -
200-32-10ug Std.: 10 ug $168.00 + -
200-32-100ug Value: 100 ug $540.00 + -
200-32-500ug Midgi: 500 ug $2,674.00 + -
200-32-1mg Mg: 1 mg $4,456.00 + -
200-32AF-2ug Animal-Free Mini: 2 ug $73.00 + -
200-32AF-10ug Animal-Free Std.: 10 ug $184.00 + -
200-32AF-100ug Animal-Free Value: 100 ug $597.00 + -
200-32AF-500ug Animal-Free Midgi: 500 ug $2,941.00 + -
200-32AF-1mg Animal-Free Mg: 1 mg $4,902.00 + -

Alternate Names:  Megakaryocyte Colony Stimulating Factor, c-MPL Ligand, MGDF               Accession Number: P40226
Description:  Thrombopoietin (TPO) is a growth factor that is produced by liver and kidney tissues. TPO binds the TPO receptor (CD110) to promote megakaryocyte maturation, differentiation, and the production of platelets.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 18.7 kDa (175 aa)
AA Sequence:  MSPVAPACDP RLLNKLLRDS HLLHSRLSQC PDVDPLSIPV LLPAVDFSLG EWKTQTEQSK AQDILGAVSL LLEGVMAARG QLEPSCLSSL LGQLSGQVRL LLGALQGLLG TQLPLQGRTT AHKDPNALFL SLQQLLRGKV RFLLLVEGPT LCVRRTLPTT AVPSSTSQLL TLNKF
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

MO7e cell proliferation

≤5 ng/mL

 
Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 1213 Lot 1213
SDS Lot 0810 Lot 0718
PDS Animal-Free Lot 0718  
SDS Animal-Free Lot 1213 Animal-Free  
  Lot 0718 Animal-Free  

 

 

 

 

Papers that use this product:
 
 
 
 2017 Jun 20;1(15):1067-1079. doi: 10.1182/bloodadvances.2016002931. eCollection 2017 Jun 27. PMID 29296749

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression.


 2015 May 7;125(19):2995-3005. doi: 10.1182/blood-2014-10-604504. Epub 2015 Mar 30. PMID 25824689

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.

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