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Mouse MCP-1 / CCL2

Monocyte chemotactic protein 1 (MCP-1), also known as CCL2, is produced by injured or infected tissues. MCP-1 signals through the CCR2 and CCR4 G protein-coupled receptors to recruit memory T cells, monocytes, and dendritic cells to sites of inflammation.

SKU Select size Price Buy
200-39-2ug Mini: 2 ug $65.00 + -
200-39-10ug Std.: 10 ug $163.00 + -
200-39-100ug Value: 100 ug $406.00 + -
200-39-500ug Midgi: 500 ug $1,752.00 + -
200-39-1mg Mg: 1 $2,920.00 + -

Alternate Names:  CCL2, JE, MCAF               Accession Number: P10148
Description:  Monocyte chemotactic protein 1 (MCP-1), also known as CCL2, is produced by injured or infected tissues. MCP-1 signals through the CCR2 and CCR4 G protein-coupled receptors to recruit memory T cells, monocytes, and dendritic cells to sites of inflammation.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 13.8 kDa (125 aa)
AA Sequence:  QPDAVNAPLT CCYSFTSKMI PMSRLESYKR ITSSRCPKEA VVFVTKLKRE VCADPKKEWV QTYIKNLDRN QMRSEPTTLF KTASALRSSA PLNVKLTRKS EANASTTFST TTSSTSVGVT SVTVN
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

THP-1 chemotaxis

≤100 ng/mL 

 
Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0909 Lot 0909
SDS    

 

 

 

Papers that use this product:

Arterioscler Thromb Vasc Biol 2018 May;38(5):994-1006.  doi: 10.1161/ATVBAHA.117.310320. Epub 2018 Mar 1. PMID 29496659

Inhibition of Local Macrophage Growth Ameliorates Focal Inflammation and Suppresses Atherosclerosis

Mol. Immunol  2016 Zhou JY, Szasz TP, Stewart-Hutchinson PJ, et al. 2016 Oct;78:79-88.  doi: 10.1016/j.molimm.2016.08.012. Epub 2016 Sep 7. PMID 27614263

L-Plastin promotes podosome longevity and supports macrophage motility. 

Julie Y Zhou 1Taylor P Szasz 1Phillip J Stewart-Hutchinson 1Janardan Sivapalan 1Elizabeth M Todd 1Lauren E Deady 1John A Cooper 2Michael D Onken 2S Celeste Morley 3

Plos One 2013 Dec 4;8(12):e81269.  doi: 10.1371/journal.pone.0081269. eCollection 2013. PMID 24324683

Lack of RNase L Attenuates Macrophage Functions

Cell 2011 Sep 16;146(6):980-91.  doi: 10.1016/j.cell.2011.08.015. PMID 21925319

Endothelial Cells Are Central Orchestrators of Cytokine Amplification During Influenza Virus Infection

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