Mouse IL-6

 Interleukin 6 (IL-6) is a cytokine that is expressed by T cells, macrophages, and muscle cells. IL-6 acts to stimulate an immune response upon infection or trauma. IL-6 has both pro-inflammatory and anti-inflammatory functions, is capable of promoting fever, and signals through the cell-surface type I cytokine receptor complex containing the IL-6Ra and gp130 chains. Human IL-6 is active on mouse and rat cells.

SKU Select size Price Buy
200-02-2ug Mini: 2 ug $63.00 + -
200-02-10ug Std.: 10 ug $158.00 + -
200-02-100ug Value: 100 ug $510.00 + -
200-02-500ug Midgi: 500 ug $1,701.00 + -
200-02-1mg Mg: 1 mg $2,835.00 + -
200-02AF-2ug Animal-Free Mini: 2 ug $69.00 + -
200-02AF-10ug Animal-Free Std.: 10 ug $174.00 + -
200-02AF-100ug Animal-Free Value: 100 ug $562.00 + -
200-02AF-500ug Animal-Free Midgi: 500 ug $1,869.00 + -
200-02AF-1mg Animal-Free Mg: 1 mg $3,119.00 + -
Alternate Names:  IFN-β2, B-cell Differentiation Factor, BSF-2, HSF, MGI-2              
Accession Number: P08505
Description:  Interleukin 6 (IL-6) is a cytokine that is expressed by T cells, macrophages, and muscle cells. IL-6 acts to stimulate an immune response upon infection or trauma. IL-6 has both pro-inflammatory and anti-inflammatory functions, is capable of promoting fever, and signals through the cell-surface type I cytokine receptor complex containing the IL-6Ra and gp130 chains. Human IL-6 is active on mouse and rat cells.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 21.9 kDa (188 aa)
AA Sequence:  MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

B9 cell proliferation

ED50 ≤ 50 pg/mL 

 
Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile 10 mM HCl at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 1116 Lot 1116
SDS Lot 1011  
PDS Animal-Free Lot 1116 Animal-Free  
SDS Animal-Free    

 

Papers that cite use of this product:
 
 
 2018 Apr 15;142(8):1702-1711. doi: 10.1002/ijc.31191. Epub 2017 Dec 12. PMID 29197088

Inhibition of MK2 suppresses IL-1β, IL-6, and TNF-α-dependent colorectal cancer growth.


 2015 May 13;4(8):569-75. doi: 10.1016/j.molmet.2015.05.001. eCollection 2015 Aug. PMID 26266089

Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance.