Mouse IL-2

Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.  IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

SKU Select size Price Buy
200-17-5ug Mini: 5 ug $63.00 + -
200-17-20ug Std.: 20 ug $158.00 + -
200-17-100ug Value: 100 ug $394.00 + -
200-17-500ug Midgi: 500 ug $1,575.00 + -
200-17-1mg Mg: 1 mg $2,625.00 + -
200-17AF-5ug Animal-Free Mini: 5 ug $69.00 + -
200-17AF-20ug Animal-Free Std.: 20 ug $174.00 + -
200-17AF-100ug Animal-Free Value: 100 ug $436.00 + -
200-17AF-500ug Animal-Free Midgi: 500 ug $1,733.00 + -
200-17AF-1mg Animal-Free Mg: 1 mg $2,888.00 + -
Alternate Names:  T cell growth factor, TCGF, Aldesleukin              
Accession Number: P04351
Description:  Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.  IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 17.4 kDa (150 aa)
AA Sequence:  MAPTSSSTSS STAEAQQQQQ QQQQQQQHLE QLLMDLQELL SRMENYRNLK LPRMLTFKFY LPKQATELKD LQCLEDELGP LRHVLDLTQS KSFQLEDAEN FISNIRVTVV KLKGSDNTFE CQFDDESATV VDFLRRWIAF CQSIISTSPQ
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, pH 4.0

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

CTLL-2 cell proliferation

≤5 ng/mL

*** International Units: The specific activity of Mouse IL-2 is approximately 1.14 x 10^5 IU/μg, which is calibrated against recombinant mouse IL-2 WHO International Standard (NIBSC code: 93/566).

Preparation and Storage:
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile 10 mM acetic acid at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0508 Lot 0119
SDS Lot 0119 Animal-Free  
PDS Animal-Free    
SDS Animal-Free    

 

 

Papers that use this product:
 
 
 2018 Mar;48(3):288-296. doi: 10.1111/cea.13075. Epub 2018 Jan 22. PMID 29247574

IgE promotes type 2 innate lymphoid cells in murine food allergy.


  2016 Sep;138(3):801-811.e9. doi: 10.1016/j.jaci.2016.02.030. Epub 2016 Apr 18. PMID 27177780
 2015 Dec;3(12):1364-74. doi: 10.1158/2326-6066.CIR-15-0087-T. Epub 2015 Aug 21. PMID 26297711

Effector CD8+ T-cell Engraftment and Antitumor Immunity in Lymphodepleted Hosts Is IL7Rα Dependent.


  2015 Oct 28;7(311):311ra170. doi: 10.1126/scitranslmed.aac8155. PMID 26511507
 2014 Nov 1;74(21):6048-59. doi: 10.1158/0008-5472.CAN-14-1450. Epub 2014 Sep 9. PMID 25205101

Reducing CD73 expression by IL1β-Programmed Th17 cells improves immunotherapeutic control of tumors.


 2013 Jul;43(7):1914-24. doi: 10.1002/eji.201243081. Epub 2013 May 28.  PMID 23616302

Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation.

Related products