Mouse Follistatin

Follistatin is an autocrine, activin-binding protein that is ubiquitously expressed with highest expression levels being in the ovary and skin.  Follistatin negatively regulates the signaling of transforming growth factor beta (TGF-β) family members, such as activin, bone morphogenetic proteins (BMPs), myostatin, growth differentiation factor 11 (GDF-11), and TGF-β1.  Follistatin functions as an antagonist by binding TGF-β family members to block interaction with their signaling receptors.  Follistatin also inhibits the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary.  

SKU Select size Price Buy
200-24-5ug Mini: 5 ug $63.00 + -
200-24-20ug Std.: 20 ug $158.00 + -
200-24-100ug Value: 100 ug $609.00 + -
200-24-500ug Midgi: 500 ug $3,024.00 + -
200-24-1mg Mg: 1 $5,040.00 + -

Alternate Names:  FS, activin-binding protein, FSH-suppressing protein (FSP)               Accession Number: P47931
Description:  Follistatin is an autocrine, activin-binding protein that is ubiquitously expressed with highest expression levels being in the ovary and skin.  Follistatin negatively regulates the signaling of transforming growth factor beta (TGF-β) family members, such as activin, bone morphogenetic proteins (BMPs), myostatin, growth differentiation factor 11 (GDF-11), and TGF-β1.  Follistatin functions as an antagonist by binding TGF-β family members to block interaction with their signaling receptors.  Follistatin also inhibits the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary.    
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 31.6 kDa (289 aa)
AA Sequence:  MGNCWLRQAK NGRCQVLYKT ELSKEECCST GRLSTSWTEE DVNDNTLFKW MIFNGGAPNC IPCKETCENV DCGPGKKCRM NKKNKPRCVC APDCSNITWK GPVCGLDGKT YRNECALLKA RCKEQPELEV QYQGKCKKTC RDVFCPGSST CVVDQTNNAY CVTCNRICPE PSSSEQYLCG NDGVTYSSAC HLRKATCLLG RSIGLAYEGK CIKAKSCEDI QCGGGKKCLW DSKVGRGRCS LCDELCPDSK SDEPVCASDN ATYASECAMK EAACSSGVLL EVKHSGSCN
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥90%

Endotoxin

Kinetic LAL

≤5 EUs/µg

Biological Activity

No biological activity data is available at this time

No biological activity data is available at this time 

 
Preparation and Storage:
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0512 Lot 0512
SDS    

 

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