Mouse IL-17A

Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins.  IL-17A is a proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes. IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion. In turn, the cytokines and chemokines mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites.

SKU Select size Price Buy
200-59-5ug Mini: 5 ug $63.00 + -
200-59-25ug Std.: 25 ug $158.00 + -
200-59-100ug Value: 100 ug $394.00 + -
200-59-500ug Midgi: 500 ug $1,701.00 + -
200-59-1mg Mg: 1 mg $2,835.00 + -
200-59AF-5ug Animal-Free Mini: 5 ug $69.00 + -
200-59AF-25ug Animal-Free Std.: 25 ug $174.00 + -
200-59AF-100ug Animal-Free Value: 100 ug $436.00 + -
200-59AF-500ug Animal-Free Midgi: 500 ug $1,869.00 + -
200-59AF-1mg Animal-Free Mg: 1 mg $3,119.00 + -

Alternate Names:  IL-17, CTLA-8               Accession Number: Q62386
Description:  Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins.  IL-17A is a proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes.  IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion.  In turn, the cytokines and chemokines mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites.  Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis.  Human, mouse, and rat IL-17A show activity on mouse cells.  
Source:  Genetically modified E.coli.
Predicted MW: Dimer, 15.1/30.2 kDa (134/268 aa)
AA Sequence:  MAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

Production of IL-6 by mouse 3T3 cells

≤5 ng/mL

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

  

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 1016 Lot 0509
SDS Lot 0509 Lot 1016
PDS Animal-Free Lot 1016 Animal-Free  
SDS Animal-Free    

 

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