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Human TGF beta 1

Transforming growth factor-beta 1 (TGF-b1) is a member of the TGF-beta superfamily of cytokines. Members of this family exhibit regulatory activity in immunity, proliferation, adhesion, migration, and growth inhibition pathways. 

SKU Select size Price Buy
100-39-5ug Mini: 5 ug $81.00 + -
100-39-20ug Std: 20 ug $293.00 + -
100-39-100ug Value: 100 ug $1,076.00 + -
100-39-500ug Midgi: 500 ug $3,239.00 + -
100-39-1mg Mg: 1 mg $5,402.00 + -

Alternate Names:  Differentiation inhibiting factor, cartilage-inducing factor               Accession Number: P01137
Description:  Transforming growth factor-beta 1 (TGF-b1) is a member of the TGF-beta superfamily of cytokines. Members of this family exhibit regulatory activity in immunity, proliferation, adhesion, migration, and growth inhibition pathways. TGF-b1 signals through SMAD proteins via the TGF-bRI and TGF-bRII receptors.  TGF-b1 is often used in addition to recombinant IL-2 for production of Treg cells in cell culture.  
Source:  Genetically modified CHO cells.
Predicted MW: Dimer, 12.8/25.6 kDa (112/224 aa)
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1 % trifluoroacetic acid (TFA) and Trehalose in a 20:1 Trehalose to protein ratio

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 


Method of Determination

Acceptance Criteria


Reducing and Non-Reducing SDS PAGE



Kinetic LAL

≤1 EUs/µg

Biological Activity

Inhibition of IL-4-induced HT-2 cell proliferation

≤500 pg/mL

 **** Reference Units: The activity of Human TFG-beta is 2.2 x 10^4 RU/μg, which was calibrated against recombinant human TGF-beta 1 NIBSC code: 89/514.

Preparation and Storage

Country of Origin:  USA       

Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C

Product Reconstitution:  Sterile 10 mM HCl at 0.1 mg/mL

Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:      

  • 12 months from date of receipt when stored at -20°C to -80°C as supplied.
  • 1 month when stored at 4°C after reconstituting as directed.
  • 3 months when stored at -20°C to -80°C after reconstituting as directed.

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Papers that use this product:
Food & Function, 2020 Jul 22;11(7):5842-5852.  doi: 10.1039/d0fo00487a.
 2019 Feb 11;10(1):701. doi: 10.1038/s41467-019-08605-3. PMID 30741923
 2019 Feb;28(2):161-168. doi: 10.1111/exd.13864. PMID 30566255

Tissue microenvironment initiates an immune response to structural components of Staphylococcus aureus.

Biol Chem 2018 Feb 23;399(3):253-264.  doi: 10.1515/hsz-2017-0217 PMID 29140787

TGF-β Requires the Activation of Canonical and Non-Canonical Signalling Pathways to Induce Skeletal Muscle Atrophy

 2017 Jun;66(6):737-751. doi: 10.1007/s00262-017-1965-3. Epub 2017 Mar 9. PMID 28280853

Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis.

 2016;40(1-2):27-38. Epub 2016 Nov 14. PMID 27842312

Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation.

 2015 Oct;17(5):376-92. doi: 10.1089/cell.2015.0040. Epub 2015 Aug 28. PMID 26317245 

Characterization and Multilineage Differentiation of Domestic and Black-Footed Cat Mesenchymal Stromal/Stem Cells from Abdominal and Subcutaneous Adipose Tissue.

 2015 Sep 15;22(10):885-93. doi: 10.1016/j.phymed.2015.06.011. Epub 2015 Jul 8. PMID 26321737

Apocynin inhibits the upregulation of TGF-β1 expression and ROS production induced by TGF-β in skeletal muscle cells.

 2014 Oct 1;549(1):134-40. doi: 10.1016/j.gene.2014.07.056. Epub 2014 Jul 23. PMID 25062971

A role for IL-10 in the transcriptional regulation of Roquin-1.


 2014 Oct 23;28(16):2375-80. doi: 10.1097/QAD.0000000000000431. PMID 25354152

Transforming growth factor beta 1 up-regulates CD169 (sialoadhesin) expression on monocyte-derived dendritic cells: role in HIV sexual transmission.

 2012 Dec 15;303(12):G1402-15. doi: 10.1152/ajpgi.00071.2012. Epub 2012 Oct 11. PMID 23064763

Hepatic microtubule acetylation and stability induced by chronic alcohol exposure impair nuclear translocation of STAT3 and STAT5B, but not Smad2/3.


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