Human IL-21

 Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells and is aberrantly expressed in Hodgkin lymphoma cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production.

SKU Select size Price Buy
100-90-2ug Mini: 2 ug $63.00 + -
100-90-10ug Std.: 10 ug $158.00 + -
100-90-100ug Value: 100 ug $609.00 + -
100-90-500ug Midgi: 500 ug $3,024.00 + -
100-90-1mg Mg: 1 mg $5,040.00 + -
100-90AF-2ug Animal-Free Mini: 2 ug $69.00 + -
100-90AF-10ug Animal-Free Std.: 10 ug $174.00 + -
100-90AF-100ug Animal-Free Value: 100 ug $667.00 + -
100-90AF-500ug Animal-Free Midgi: 500 ug $3,329.00 + -
100-90AF-1mg Animal-Free Mg: 1 mg $5,544.00 + -

Accession Number: Q9HBE4
Description:  Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells and is aberrantly expressed in Hodgkin lymphoma cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with IL-4 for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 15.4 kDa (132 aa)
AA Sequence:  MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

B9 cell proliferation
ED50 ≤ 50 ng/mL
 
Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0713 Lot 0219
SDS Lot 0613 Lot 0713
PDS Animal-Free Lot 0508  
SDS Animal-Free Lot 0219  
  Lot 0713 Animal-Free  
  Lot 0219 Animal-Free  

 

 

 

Papers that cite this product:
 
 
 

Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.

 


 2012 Jan 12;119(2):368-76. doi: 10.1182/blood-2011-06-360354. Epub 2011 Oct 24. PMID 22025529

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