Human IL-2

Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.  IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

SKU Select size Price Buy
100-12-10ug Mini: 10 ug $63.00 + -
100-12-50ug Std.: 50 ug $158.00 + -
100-12-100ug Value: 100 ug $284.00 + -
100-12-500ug Midgi: 500 ug $394.00 + -
100-12-1mg Mg: 1 mg $683.00 + -
100-12AF-10ug Animal-Free Mini: 10 ug $69.00 + -
100-12AF-50ug Animal-Free Std.: 50 ug $174.00 + -
100-12AF-100ug Animal-Free Value: 100 ug $310.00 + -
100-12AF-500ug Animal-Free Midgi: 500 ug $431.00 + -
100-12AF-1mg Animal-Free Mg: 1 mg $751.00 + -

Alternate Names:  T cell growth factor, TCGF, Aldesleukin              

Accession Number: P60568
Description:  Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.  IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 15.5 kDa (134 aa)
AA Sequence:  MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFCQSII STLT
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

CTLL-2 cell proliferation

 

≤3 ng/mL; ≥ 3.3 x 10^5 units/mg

 

**** International Units: The specific activity of Human IL-2 is approximately 1.8 x 10^4 IU/μg, which is calibrated against recombinant human IL-2 WHO International Standard (NIBSC code: 86/500).

 Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile 10 mM HCl at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

 

Complementary antibody products:
Need an Anti-Human IL-2 antibody?  We recommend Anti-Human IL-2 Rabbit Polyclonal Antibody from ImmunoReagents.  If you are curious to know more about the relationship between Shenandoah and Immunoreagents, click here for the scoop.

To receive more information or a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 1111 Lot 0319
SDS Lot 0319 Lot 0419
PDS Animal-Free Lot 0817 Lot 0817
SDS Animal-Free Lot 0319 Animal-Free Lot 07191
  Lot 0817 Animal-Free  

Papers that use this product:

 

A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers

 2019 Jul 23;28(4):1063-1073.e5. doi: 10.1016/j.celrep.2019.06.084. PMID 31340144

 2019 Jul 15;203(2):338-348. doi: 10.4049/jimmunol.1801651. Epub 2019 Jun 3. PMID 31160534

Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells.


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