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Human IL-13

Interleukin 13 (IL-13) is a cytokine secreted from type 2 T helper (Th2) cells.  IL-13 has overlapping functions with interleukin 4 (IL-4), including the induction of immunoglobulin E (IgE) secretion from B cells, and the inhibition of interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), interleukin 8 (IL-8), and interleukin 6 (IL-6) inflammatory cytokine expression.  IL-13 also regulates immune cell inflammation in response to the pathophysiological changes of surrounding non-immune cells.

SKU Select size Price Buy
100-85-2ug Mini: 2 ug $63.00 + -
100-85-10ug Std.: 10 ug $158.00 + -
100-85-100ug Value: 100 ug $609.00 + -
100-85-500ug Midgi: 500 ug $3,024.00 + -
100-85-1mg Mg: 1 mg $5,040.00 + -

Alternate Names:  NC30              

Accession Number: P35225
Description:  Interleukin 13 (IL-13) is a cytokine secreted from type 2 T helper (Th2) cells.  IL-13 has overlapping functions with interleukin 4 (IL-4), including the induction of immunoglobulin E (IgE) secretion from B cells, and the inhibition of interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), interleukin 8 (IL-8), and interleukin 6 (IL-6) inflammatory cytokine expression.  IL-13 also regulates immune cell inflammation in response to the pathophysiological changes of surrounding non-immune cells.  The IL-13 receptor consists of the IL-4Ra and IL-13Ra1 subunits.  IL-13 can also bind the IL-13Ra2 receptor with high affinity.  IL-13 functions are mediated through the JAK/STAT signaling pathway.  Human and mouse IL-13 are cross-reactive.  
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 12.6 kDa (115 aa)
AA Sequence:  MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, pH 3.0

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

TF-1 cell proliferation

≤5 ng/mL

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile 10 mM HCl at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origins
PDS Lot 0908 Lot 0908
SDS    

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