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Human CTGF

Connective tissue growth factor (CTGF) is a mitogen that is secreted by vascular endothelial cells in response to basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF). CTGF promotes cell growth, migration, adhesion, and survival of endothelial cells. CTGF is also important during osteogenesis, chondrogenesis, and skeletogenesis. CTGF has an insulin-like growth factor binding protein (IGFBP) domain, a thrombospondin type 1 repeat (TSR) domain, and a C-terminal cysteine knot motif.

SKU Select size Price Buy
100-60-5ug Mini: 5 ug $67.00 + -
100-60-20ug Std.: 20 ug $168.00 + -
100-60-100ug Value: 100 ug $429.00 + -
100-60-500ug Midgi: 500 ug $2,139.00 + -
100-60-1mg Mg: 1 $3,565.00 + -
Alternate Names:  CCN2, HCS24               Accession Number: P29279
Description:  Connective tissue growth factor (CTGF) is a mitogen that is secreted by vascular endothelial cells in response to basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF). CTGF promotes cell growth, migration, adhesion, and survival of endothelial cells. CTGF is also important during osteogenesis, chondrogenesis, and skeletogenesis. CTGF has an insulin-like growth factor binding protein (IGFBP) domain, a thrombospondin type 1 repeat (TSR) domain, and a C-terminal cysteine knot motif.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 11.2 kDa (98 aa)
AA Sequence:   MGKKCIRTPK ISKPIKFELS GCTSMKTYRA KFCGVCTDGR CCTPHRTTTL PVEFKCPDGE VMKKNMMFIK TCACHYNCPG DNDIFESLYY RKMYGDMA
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥90%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

HUVEC Proliferation

ED50 ≤2,000 ng/mL 

 
Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

  

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0612 Lot 0612
SDS    

Papers this product is used in:

 

 2015 Sep;138:52-8. doi: 10.1016/j.exer.2015.06.028. Epub 2015 Jul 2. PMID 26142957

Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts.

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