Mouse IL-4 Gel
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Mouse IL-4

Animal-Free (AF) proteins are identical to regular proteins and include additional documentation showing that they were produced with no materials of animal or human origin using ANIMAL-FREE purification processes.  Learn more HERE.

SKU Select size Price Buy
200-18-5ug Mini: 5 ug $63.00 + -
200-18-20ug Std.: 20 ug $158.00 + -
200-18-100ug Value: 100 ug $410.00 + -
200-18-500ug Midgi: 500 ug $2016.00 + -
200-18-1mg Mg: 1 mg $3360.00 + -
200-18AF-5ug Animal-Free Mini: 5 ug $69.00 + -
200-18AF-20ug Animal-Free Std.: 20 ug $174.00 + -
200-18AF-100ug Animal-Free Value: 100 ug $436.00 + -
200-18AF-500ug Animal-Free Midgi: 500 ug $2142.00 + -
200-18AF-1mg Animal-Free Mg: 1 mg $3570.00 + -
  • Weight
    0.0100 lbs
  • SKU
    200-18-5ug
Alternate Names:  B cell Stimulating Factor, BSF-1, BCDF, BCGF              
Accession Number: P07750
Description:  Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 13.7 kDa (121 aa)
AA Sequence:  MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

HT-2 proliferation

≤20 ng/mL; ≥ 5.0 x 10^4 units/mg

 

 **** International Units: The specific activity of Mouse IL-4 is approximately 2.5 x 10^4 IU/μg, which is calibrated against recombinant mouse IL-4 WHO International Standard (NIBSC code: 91/656). 

Preparation and Storage:
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or a quote, complete our bulk/custom order form.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 1111 Lot 0613
SDS Lot 0613 Lot 0217
PDS Animal-Free Lot 0217 Lot 1111
SDS Animal-Free Lot 0613 Animal-Free   
  Lot 0217 Animal-Free  

 

 

 

Papers that use this product:
 
 
 2019 Apr;176(7):938-949. doi: 10.1111/bph.14597. Epub 2019 Mar 14.

Blockage of sphingosine-1-phosphate receptor 2 attenuates allergic asthma in mice.


 

 2018 Jan;141(1):189-201.e3. doi: 10.1016/j.jaci.2017.03.045. Epub 2017 May 4.
 2016 Apr 22;5(6):e1173299. doi: 10.1080/2162402X.2016.1173299. eCollection 2016 Jun.

Murine mesothelioma induces locally-proliferating IL-10(+)TNF-α(+)CD206(-)CX3CR1(+) M3 macrophages that can be selectively depleted by chemotherapy or immunotherapy.

 

 2014 Jun;36(3):9655. doi: 10.1007/s11357-014-9655-y. Epub 2014 Apr 19.

IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice.


 2013 Jun;218(6):844-50. doi: 10.1016/j.imbio.2012.10.003. Epub 2012 Oct 17.

Role of complement in a murine model of peanut-induced anaphylaxis.

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