Human TGF-alpha

Tumor growth factor alpha (TGF-α) is a member of the epidermal growth factor (EGF) family. TGF-α function is mediated through binding the EGF receptor (EGFR) to activate receptor tyrosine kinase signaling.  TGF-α functions as a mitogen to activate epithelial cell proliferation, growth, and differentiation.

SKU Select size Price Buy
100-209-25ug Mini: 25 ug $63.00 + -
100-209-100ug Std.: 100 ug $158.00 + -
100-209-250ug Value: 250 ug $342.00 + -
100-209-500ug Midgi: 500 ug $630.00 + -
100-209-1mg Mg: 1 mg $1,103.00 + -
100-209AF-25ug Animal-Free Mini: 25 ug $69.00 + -
100-209AF-100ug Animal-Free Std.: 100 ug $174.00 + -
100-209AF-250ug Animal-Free Value: 250 ug $378.00 + -
100-209AF-500ug Animal-Free Midgi: 500 ug $693.00 + -
100-209AF-1mg Animal-Free Mg: 1 mg $1,213.00 + -

Alternate Names:  TGF-alpha, EGF-like TGF, ETGF, TGFA, TGF type 1                     

Accession Number: P01135           
Description:  Tumor growth factor alpha (TGF-α) is a member of the epidermal growth factor (EGF) family. TGF-α function is mediated through binding the EGF receptor (EGFR) to activate receptor tyrosine kinase signaling.  TGF-α functions as a mitogen to activate epithelial cell proliferation, growth, and differentiation.  In the gastric mucosa, TGF-α production inhibits gastric acid secretion and therefore plays a central role in the pathogenesis of the stomach syndrome Ménétrier's disease.  TGF-α is also produced in adult macrophages, brain cells, keratinocytes, and is widely expressed in cancer cells. 
Source:  Genetically modified E.coli
Predicted MW:  Monomer, 5.6 kDa (with 50 amino acids)
AA Sequence:  VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each production lot on its corresponding COA. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS-PAGE

≥ 95%

Endotoxin

Kinetic LAL (50% confidence)

≤ 1 EUs/µg

Biological Activity

3T3 cell proliferation

ED50 ≤ 2 ng/mL 


Preparation and Storage

Country of Origin:  USA         Shipping:  Room temperature              

Storage Prior to Reconstitution:  -20°C

Product Reconstitution:  Sterile water at 0.1 mg/mL    

Instructions:  Centrifuge vial before opening.  Suspend the product by gently pipetting the above recommended solution down the sides of the vial.  DO NOT VORTEX.  Allow several minutes for complete reconstitution.  For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.   


Expiration Date:                      

12 months from date of receipt when stored at -20°C to -80°C as supplied. 

1 month when stored at 4°C after reconstituting as directed.

3 months when stored at -20°C to -80°C after reconstituting as directed.

                                                                                   

THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS!           

 

To receive more information or a bulk quote, email us at quotes@shenandoah-bt.com.

  

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 1117 Lot 1117
SDS Lot 1117 Animal-Free  
PDS Animal-Free    
SDS Animal-Free    

 

 

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