Human SCF

Stem cell factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in the maintenance, survival, and differentiation of hematopoietic stem cells. While human SCF shows no activity on murine cells, murine and rat SCF are active on human cells.

SKU Select size Price Buy
100-04-2ug Mini: 2 ug $63.00 + -
100-04-10ug Std.: 10 ug $158.00 + -
100-04-100ug Value: 100 ug $394.00 + -
100-04-500ug Midgi: 500 ug $1,323.00 + -
100-04-1mg Mg: 1 mg $2,205.00 + -
100-04AF-2ug Animal-Free Mini: 2 ug $69.00 + -
100-04AF-10ug Animal-Free Std.: 10 ug $174.00 + -
100-04AF-100ug Animal-Free Value: 100 ug $436.00 + -
100-04AF-500ug Animal-Free Midgi: 500 ug $1,455.00 + -
100-04AF-1mg Animal-Free Mg: 1 mg $2,426.00 + -

Alternate Names:  c-Kit Ligand, KL, Steel Factor, MGF               Accession Number: P21583
Description:  Stem cell factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in the maintenance, survival, and differentiation of hematopoietic stem cells. While human SCF shows no activity on murine cells, murine and rat SCF are active on human cells.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 18.6 kDa (165 aa)
AA Sequence:  MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5.

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

TF-1 cell proliferation

≤15 ng/mL; ≥ 6.7 x 10^4 units/mg

 

Preparation and Storage

Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL.
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

 

To receive more information or for a bulk quote, email quotes@shenandoah-bt.com.

  

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0417 Lot 0417
SDS Lot 0213 Lot 0419
PDS Animal-Free Lot 0717 Lot 0817
SDS Animal-Free Lot 0817 Lot 10191
  Lot 0417 Animal-Free  
  Lot 0213 Animal-Free  
Papers that use this product:
 
 
 
 2019 May 23. pii: haematol.2018.212886. doi: 10.3324/haematol.2018.212886. [Epub ahead of print] PMID 31123028

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia.


 2018 Jun 6;9:1244. doi: 10.3389/fimmu.2018.01244. eCollection 2018. PMID 29928276

Tissue-Specific Expression of the Low-Affinity IgG Receptor, FcγRIIb, on Human Mast Cells.


 2014 May;133(5):1356-64, 1364.e1-14. doi: 10.1016/j.jaci.2013.11.030. Epub 2014 Jan 22. PMID 24461581

Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation.

Related products