Human RANK Ligand

Receptor activator of nuclear factor kappa-B Ligand (RANK Ligand) is a cell-bound marker related to the tumor necrosis factor (TNF) family of proteins. RANK Ligand plays a critical role in bone metabolism and osteoclast differentiation. T cell expression of RANK Ligand promotes dendritic cell maturation.

SKU Select size Price Buy
100-19-2ug Mini: 2 ug $63.00 + -
100-19-10ug Std.: 10 ug $158.00 + -
100-19-100ug Value: 100 ug $609.00 + -
100-19-500ug Midgi: 500 ug $3,024.00 + -
100-19-1mg Mg: 1 mg $5,040.00 + -
100-19AF-2ug Animal-Free Mini: 2 ug $69.00 + -
100-19AF-10ug Animal-Free Std.: 10 ug $174.00 + -
100-19AF-100ug Animal-Free Value: 100 ug $667.00 + -
100-19AF-500ug Animal-Free Midgi: 500 ug $3,329.00 + -
100-19AF-1mg Animal-Free Mg: 1 mg $5,544.00 + -

Alternate Names:  TNFSF11, TRANCE, OPGL, ODF               Accession Number: O14788
Description:  Receptor activator of nuclear factor kappa-B Ligand (RANK Ligand) is a cell-bound marker related to the tumor necrosis factor (TNF) family of proteins. RANK Ligand plays a critical role in bone metabolism and osteoclast differentiation. T cell expression of RANK Ligand promotes dendritic cell maturation.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 19.7 kDa (175 aa)
AA Sequence:  EKAMVDGSWL DLAKRSKLEA QPFAHLTINA TDIPSGSHKV SLSSWYHDRG WAKISNMTFS NGKLIVNQDG FYYLYANICF RHHETSGDLA TEYLQLMVYV TKTSIKIPSS HTLMKGGSTK YWSGNSEFHF YSINVGGFFK LRSGEEISIE VSNPSLLDPD QDATYFGAFK VRDID
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

Activity of RAW-BlueTM cells

ED50 ≤ 50 ng/mL 

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 1213 Lot 0117
SDS Lot 0318 Lot 0318
PDS Animal-Free Lot 1117  
SDS Animal-Free Lot 1213 Animal-Free  
  Lot 0318 Animal-Free  
  Lot 1117 Animal-Free  
Papers that use this product:  
 
 
 
 2018 Jan;106:194-203. doi: 10.1016/j.bone.2017.09.020. Epub 2017 Sep 28. PMID 28965919

Pulsed electromagnetic fields inhibit human osteoclast formation and gene expression via osteoblasts.


 2017 Dec;35(12):2658-2666. doi: 10.1002/jor.23587. Epub 2017 Jul 18. PMID 28460421

Calreticulin inhibits inflammation-induced osteoclastogenesis and bone resorption.

Fischer CR1Mikami M1Minematsu H1Nizami S1Goo Lee H1Stamer D2Patel N2Yu Soung D1Back JH2Song L1Drissi H3Lee FY2.
 2011 Jun;28(6):1357-69. doi: 10.1007/s11095-010-0351-z. Epub 2010 Dec 30. PMID 21191633

Blocking IKKα expression inhibits prostate cancer invasiveness.

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