Human Pleiotrophin

Pleiotrophin (PTN) is a heparin-binding growth factor that has mitogenic effects on fibroblast, epithelial, and endothelial cells. PTN is made by many tissues, but is predominantly secreted by nervous tissue during development. PTN induces neurite outgrowth and is involved in tumor growth and metastasis.

SKU Select size Price Buy
100-55-5ug Mini: 5 ug $63.00 + -
100-55-20ug Std.: 20 ug $158.00 + -
100-55-100ug Value: 100 ug $394.00 + -
100-55-500ug Midgi: 500 ug $1,701.00 + -
100-55-1mg Mg: 1 mg $2,835.00 + -
100-55AF-5ug Animal-Free Mini: 5 ug $69.00 + -
100-55AF-20ug Animal-Free Std.: 20 ug $174.00 + -
100-55AF-100ug Animal-Free Value: 100 ug $436.00 + -
100-55AF-500ug Animal-Free Midgi: 500 ug $1,869.00 + -
100-55AF-1mg Animal-Free Mg: 1 mg $3,119.00 + -

Alternate Names:  HBBM, HBGF-8, NEGF1, HARP               Accession Number: P21246
Description:  Pleiotrophin (PTN) is a heparin-binding growth factor that has mitogenic effects on fibroblast, epithelial, and endothelial cells. PTN is made by many tissues, but is predominantly secreted by nervous tissue during development. PTN induces neurite outgrowth and is involved in tumor growth and metastasis. PTN binds with low affinity to the cell surface receptor nucleolin to inhibit HIV-1 infection. PNT also binds the receptor protein tyrosine phosphatase type Z (PTPRZ), syndecan-3, and anaplastic lymphoma kinase (ALK) receptors.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 15.4 kDa (137 aa)
AA Sequence:  MGKKEKPEKK VKKSDCGEWQ WSVCVPTSGD CGLGTREGTR TGAECKQTMK TQRCKIPCNW KKQFGAECKY QFQAWGECDL NTALKTRTGS LKRALHNAEC QKTVTISKPC GKLTKPKPQA ESKKKKKEGK KQEKMLD
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

No biological activity data is available at this time

No biological activity data is available at this time 

 
Preparation and Storage:
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 1213 Lot 1213
SDS Lot 1213 Animal-Free  
PDS Animal-Free    
SDS Animal-Free    

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