Human NRG1-beta

Neuregulin 1-beta (NRG1-β) is one of many alternatively-spliced isoforms of the NRG1 gene and contains a soluble EGF-like domain. The EGF-like domain of NRG1-β signals through the ErbB2, ErbB3, and ErbB4 receptor tyrosine kinases. NRG1-β is an important growth factor involved in neuroinflammation, nerve regeneration, and cardiovascular processes.

SKU Select a Size Price Buy
100-46-10ug Mini: 10 ug $63.00 + -
100-46-50ug Std.: 50 ug $158.00 + -
100-46-100ug Value: 100 ug $284.00 + -
100-46-500ug Midgi: 500 ug $725.00 + -
100-46-1mg Mg: 1 mg $1,260.00 + -
100-46AF-10ug Animal-Free Mini: 10 ug $69.00 + -
100-46AF-50ug Animal-Free Std.: 50 ug $174.00 + -
100-46AF-100ug Animal-Free Value: 100 ug $310.00 + -
100-46AF-500ug Animal-Free Midgi: 500 ug $819.00 + -
100-46AF-1mg Animal-Free Mg: 1 mg $1,386.00 + -
Alternate Names:  NGR beta 1, neuregulin, HRG1 beta              
Accession Number: Q02297-6
Description:  Neuregulin 1-beta (NRG1-β) is one of many alternatively-spliced isoforms of the NRG1 gene and contains a soluble EGF-like domain. The EGF-like domain of NRG1-β signals through the ErbB2, ErbB3, and ErbB4 receptor tyrosine kinases. NRG1-β is an important growth factor involved in neuroinflammation, nerve regeneration, and cardiovascular processes.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 7.6 kDa (66 aa)
AA Sequence:  MSHLVKCAEK EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAE
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

No biological activity data is available at this time

No biological activity data is available at this time 

 
Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0713 Lot 0615
SDS Lot 0615  
PDS Animal-Free Lot 0615 Animal-Free  
SDS Animal-Free    
Papers that use this product:
 
 
 2019 Apr 7;2019:8397158. doi: 10.1155/2019/8397158. eCollection 2019. PMID 31089334

Neuregulin-1 Fosters Supportive Interactions between Microglia and Neural Stem/Progenitor Cells.


 2017 Feb;113(Pt A):386-395. doi: 10.1016/j.neuropharm.2016.10.021. Epub 2016 Oct 23. PMID 27784625
 2017 Sep 10;261:147-162. doi: 10.1016/j.jconrel.2017.06.030. Epub 2017 Jun 28. PMID 28668379
 

 2014 Aug;148(3-4):121-9. doi: 10.1016/j.anireprosci.2014.05.002. Epub 2014 Jun 2. PMID 24962614

 2013 Jul 30;8(7):e70338. doi: 10.1371/journal.pone.0070338. Print 2013. PMID 23936190
 2010 Jun;70(7):498-507. doi: 10.1002/dneu.20793. PMID 20213761