Human / Mouse TGF-beta 3 (Lyophilized)

Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues.

SKU Select size Price Buy
800-11-2ug Mini: 2 ug $63.00 + -
800-11-10ug Std.: 10 ug $158.00 + -
800-11-100ug Value: 100 ug $615.00 + -
800-11-500ug Midgi: 500 ug $3,024.00 + -
800-11-1mg Mg: 1 mg $5,040.00 + -
800-11AF-2ug Animal-Free Mini: 2 ug $69.00 + -
800-11AF-10ug Animal-Free Std.: 10 ug $174.00 + -
800-11AF-100ug Animal-Free Value: 100 ug $678.00 + -
800-11AF-500ug Animal-Free Midgi: 500 ug $3,329.00 + -
800-11AF-1mg Animal-Free Mg: 1 mg $5,544.00 + -

Accession Number: P10600/P17125          
Description:  Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.
Source:  Genetically modified E.coli.
Predicted MW: Dimer, 12.9/25.7 kDa (113/226 aa)
AA Sequence:  MALDTNYCFR NLEENCCVRP LYIDFRQDLG WKWVHEPKGY YANFCSGPCP YLRSADTTHS TVLGLYNTLN PEASASPCCV PQDLEPLTIL YYVGRTPKVE QLSNMVVKSC KCS
Formulation: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

Inhibition of IL-4-induced HT-2 cell proliferation

ED50 ≤1 ng/mL 

Preparation and Storage

Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL 

Instructions:  Centrifuge vial before opening.  Suspend the product by gently pipetting the above recommended solution down the sides of the vial.  DO NOT VORTEX.  Allow several minutes for complete reconstitution.  For prolonged storage, dilute to working aliquots in a 0.1% BSA solution.   


Expiration Date:                      
12 months from date of receipt when stored at -20°C to -80°C as supplied. 
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0519 Lot 0519
SDS Lot 0519 Animal-Free  
PDS Animal-Free     
SDS Animal-Free    

 

Papers that cite this product:
 
 
 2017 Jun;66(6):737-751. doi: 10.1007/s00262-017-1965-3. Epub 2017 Mar 9. PMID 28280853

Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis.

 

 2014 Oct 1;549(1):134-40. doi: 10.1016/j.gene.2014.07.056. Epub 2014 Jul 23. PMID 25062971

A role for IL-10 in the transcriptional regulation of Roquin-1.



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