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Human IL-6
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Human IL-6

Animal-Free (AF) proteins are identical to regular proteins and include additional documentation showing that they were produced with no materials of animal or human origin using ANIMAL-FREE purification processes.  Learn more HERE.

SKU Select size Price Buy
100-10-5ug Mini: 5 ug $63.00 + -
100-10-20ug Std.: 20 ug $158.00 + -
100-10-100ug Value: 100 ug $394.00 + -
100-10-500ug Midgi: 500 ug $1701.00 + -
100-10-1mg Mg: 1 mg $2835.00 + -
100-10AF-5ug Animal-Free Mini: 5 ug $69.00 + -
100-10AF-20ug Animal-Free Std.: 20 ug $174.00 + -
100-10AF-100ug Animal-Free Value: 100 ug $436.00 + -
100-10AF-500ug Animal-Free Midgi: 500 ug $1869.00 + -
100-10AF-1mg Animal-Free Mg: 1 mg $3119.00 + -
  • Weight
    0.0100 lbs
  • SKU
    100-10-5ug

Alternate Names:  IFN-β2, B-cell Differentiation Factor, BSF-2, HSF, MGI-2              

Accession Number: P05231
Description:  Interleukin 6 (IL-6) is an important pro-inflammatory and anti-inflammatory cytokine expressed by T cells, macrophages and muscle cells. IL-6 signals through a receptor complex containing two receptors, IL-6Rα and gp130. IL-6 has an important function in promoting fever and can serve to stimulate an immune response to trauma. IL-6 is often used for growth of hybridoma cell lines. Human IL-6 is active on mouse and rat cells.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 21 kDa (185 aa)
AA Sequence:  MPVPPGEDSK DVAAPHRQPL TSSERIDKQI RYILDGISAL RKETCNKSNM CESSKEALAE NNLNLPKMAE KDGCFQSGFN EETCLVKIIT GLLEFEVYLE YLQNRFESSE EQARAVQMST KVLIQFLQKK AKNLDAITTP DPTTNASLLT KLQAQNQWLQ DMTTHLILRS FKEFLQSSLR ALRQM
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

7TD1 cell proliferation OR

B9 cell proliferation

 ≤250 pg/mL; ≥ 4.0 x 10^6 units/mg OR

≤25 pg/mL; ≥ 4.0 x 10^7 units/mg

 

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

 

Complementary Antibody products:
Need an Anti-Human IL-6 antibody?  We recommend Anti-Human IL-6 Rabbit Polyclonal Antibody or Anti-Human IL-6 Mouse Monoclonal Antibody from ImmunoReagents.  If you are curious to know more about the relationship between Shenandoah and Immunoreagents, click here for the scoop.

To receive more information or a quote, complete our bulk/custom order form.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0213 Lot 0213
SDS Lot 0507 Lot 0617
PDS Animal-Free Lot 0617 Lot 1118
SDS Animal-Free Lot 0213 Animal-Free  
  Lot 0617 Animal-Free  
Papers that use this product:
 
 
 
 2017 Jun 20;1(15):1067-1079. doi: 10.1182/bloodadvances.2016002931. eCollection 2017 Jun 27. PMID 29296749
 2016 May;97(5):1077-1086. doi: 10.1099/jgv.0.000441. Epub 2016 Mar 1. PMID 26932515

Characterization of Nipah virus infection in a model of human airway epithelial cells cultured at an air-liquid interface.

 

 2014 Dec 19;289(51):35159-71. doi: 10.1074/jbc.M114.600767. Epub 2014 Oct 30. PMID 25359776

Cytoskeletal regulation of CD44 membrane organization and interactions with E-selectin.


 2014 May;133(5):1356-64, 1364.e1-14. doi: 10.1016/j.jaci.2013.11.030. Epub 2014 Jan 22. PMID 24461581

Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation.


 2012 Dec 15;303(12):G1402-15. doi: 10.1152/ajpgi.00071.2012. Epub 2012 Oct 11. PMID 23064763

Hepatic microtubule acetylation and stability induced by chronic alcohol exposure impair nuclear translocation of STAT3 and STAT5B, but not Smad2/3.

 
 
 
 
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