Human IL-3

Interleukin 3 (IL-3) is a cytokine that is produced by activated T cells and mast cells. IL-3 induces the differentiation of hematopoietic stem cells into myeloid precursor cells, such as erythrocyte, megakaryocyte, granulocyte, monocyte, and dendritic cells. IL-3 also functions in the nervous system and is important during the B-1 cell regulation of chronic inflammatory diseases.

SKU Select size Price Buy
100-80-2ug Mini: 2 ug $63.00 + -
100-80-10ug Std.: 10 ug $158.00 + -
100-80-100ug Value: 100 ug $394.00 + -
100-80-500ug Midgi: 500 ug $1,701.00 + -
100-80-1mg Mg: 1 mg $2,835.00 + -
100-80AF-2ug Animal-Free Mini: 2 ug $69.00 + -
100-80AF-10ug Animal-Free Std.: 10 ug $174.00 + -
100-80AF-100ug Animal-Free Value: 100 ug $436.00 + -
100-80AF-500ug Animal-Free Midgi: 500 ug $1,869.00 + -
100-80AF-1mg Animal-Free Mg: 1 mg $3,119.00 + -
Alternate Names:  MCGF, Multi-CSF, HCGF, P-cell stimulating factor              
Accession Number: P08700
Description:  Interleukin 3 (IL-3) is a cytokine that is produced by activated T cells and mast cells. IL-3 induces the differentiation of hematopoietic stem cells into myeloid precursor cells, such as erythrocyte, megakaryocyte, granulocyte, monocyte, and dendritic cells. IL-3 also functions in the nervous system and is important during the B-1 cell regulation of chronic inflammatory diseases.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 15.2 kDa (134 aa)
AA Sequence:  MAPMTQTTPL KTSWVNCSNM IDEIITHLKQ PPLPLLDFNN LNGEDQDILM ENNLRRPNLE AFNRAVKSLQ NASAIESILK NLLPCLPLAT AAPTRHPIHI KDGDWNEFRR KLTFYLKTLE NAQAQQTTLS LAIF
Formulation: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.5.

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

TF-1 cell proliferation

≤2 ng/mL

 *** International Units: The specific activity of Human IL-3 is approximately 4.2 x 10^3 IU/μg, which is calibrated against recombinant human IL-3 WHO International Standard (NIBSC code: 91/510).

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 1215 Lot 0417
SDS Lot 1008 Lot 1215
PDS Animal-Free Lot 0417  
SDS Animal-Free Lot 0213  
  Lot 1215 Animal-Free  
  Lot 0417 Animal-Free  
  Lot 0213 Animal-Free  
Papers that use this product:
 
 
 2019 May 23. pii: haematol.2018.212886. doi: 10.3324/haematol.2018.212886. PMID 31123028

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia.


 2017 Nov 8;12(11):e0187415. doi: 10.1371/journal.pone.0187415. eCollection 2017. PMID 29117222
 2017 Jan;139(1):314-322.e9. doi: 10.1016/j.jaci.2016.04.034. Epub 2016 Jun 8. PMID 27417025

A humanized mouse model of anaphylactic peanut allergy.


 2014 May;133(5):1356-64, 1364.e1-14. doi: 10.1016/j.jaci.2013.11.030. Epub 2014 Jan 22. PMID 24461581

Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation.

 
 

 

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