Human IGF-I

Insulin-like growth factor I (IGF-I) is a growth factor that is produced by the liver. IGF-1 production is stimulated by growth hormone (GH). IGF-I binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth.

SKU Select size Price Buy
100-34-20ug Mini: 20 ug $63.00 + -
100-34-100ug Std.: 100 ug $158.00 + -
100-34-1mg Value: 1 mg $263.00 + -
100-34-5mg Mg: 5 mg $1,182.00 + -
100-34AF-20ug Animal-Free Mini: 20 ug $69.00 + -
100-34AF-100ug Animal-Free Std.: 100 ug $174.00 + -
100-34AF-1mg Animal-Free Value: 1 mg $289.00 + -
100-34AF-5mg Animal-Free Mg: 5 mg $1,302.00 + -
Alternate Names:  Somatomedin C, mechano growth factor, IGF-IA              
Accession Number: P05019
Description:  Insulin-like growth factor I (IGF-I) is a growth factor that is produced by the liver. IGF-1 production is stimulated by growth hormone (GH). IGF-I binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-I is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death. Mature human IGF-I is 100% homologous to bovine and porcine IGF-1 proteins.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 7.7 kDa (70 aa)
AA Sequence:  GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

FDC-P1 cell proliferation

≤10 ng/mL

 
Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

 

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Papers that use this product:
 
 
 
 2019 Jun;18(3):406-421. doi: 10.1007/s12311-019-1007-0. PMID 30729383

An Improved Method for Differentiating Mouse Embryonic Stem Cells into Cerebellar Purkinje Neurons.

H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulphonamide) induces autophagy independently of protein kinase A inhibition.


 2012 Apr;90(4):1126-33. doi: 10.2527/jas.2011-4358. Epub 2011 Nov 18.  PMID 22100600

Growth hormone stimulates protein synthesis in bovine skeletal muscle cells without altering insulin-like growth factor-I mRNA expression.

 
 
 
 

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