Human GDNF

Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signaling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons.

SKU Select size Price Buy
100-02-2ug Mini: 2 ug $63.00 + -
100-02-10ug Std.: 10 ug $158.00 + -
100-02-100ug Value: 100 ug $609.00 + -
100-02-500ug Midgi: 500 ug $3,024.00 + -
100-02-1mg Mg: 1 mg $5,040.00 + -
100-02AF-2ug Animal-Free Mini: 2 ug $69.00 + -
100-02AF-10ug Animal-Free Std.: 10 ug $174.00 + -
100-02AF-100ug Animal-Free Value: 100 ug $667.00 + -
100-02AF-500ug Animal-Free Midgi: 500 ug $3,329.00 + -
100-02AF-1mg Animal-Free Mg: 1 mg $5,544.00 + -

Alternate Names:  ATF-1               Accession Number: P39905
Description:  Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signaling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons.
Source:  Genetically modified E.coli.
Predicted MW: Dimer, 15.2/30.4 kDa (135/270 aa)
AA Sequence:  MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, 100 mM sodium chloride, pH 4.0

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

C6 proliferation

≤3 ug/mL; ≥ 3.3 x 10^2 units/mg

 

 

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

 

To receive more information or for a bulk quote, email quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0515 Lot 1116
SDS Lot 0808  
PDS Animal-Free Lot 1116  
SDS Animal-Free Lot 1116 Animal-Free  
  Lot 0515 Animal-Free  
Papers that cite this product:
 
 
Neurobiol Aging 2020 Jun;90:125-134.  doi: 10.1016/j.neurobiolaging.2020.02.011. Epub 2020 Feb 19. PMID: 32184029
J. Clin. Invest. 2020 Jun 2;130176.  doi: 10.1172/JCI130176. PMID  32484462

Cell Tissue Res 2019 Mar;375(3):641-654. doi: 10.1007/s00441-018-2942-7. Epub 2018 Nov 8. PMID 30406823

The Effect of Rho Kinase Inhibition on Morphological and Electrophysiological Maturity in iPSC-derived Neurons

 2019 Aug;95(8):825-835. doi: 10.1002/cyto.a.23783. Epub 2019 May 7. PMID 31063256

Imaging Flow Cytometry Quantifies Neural Genome Dynamics.


 2019 Jun;69(6):2455-2470. doi: 10.1002/hep.30541. Epub 2019 Mar 22. PMID 30715741

Glial Cell Line-Derived Neurotrophic Factor Enhances Autophagic Flux in Mouse and Rat Hepatocytes and Protects Against Palmitate Lipotoxicity.

Mwangi SM1,2Li G1,2Ye L1,2Liu Y1Reichardt F1,2Yeligar SM3,4Hart CM3,4Czaja MJ1Srinivasan S1,2.

 2017 Mar 1;595(5):1831-1846. doi: 10.1113/JP273269. Epub 2017 Feb 8. PMID 28000223

Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and lipopolysaccharide-induced TLR4 signalling.

 

 2015 May;125(5):1873-85. doi: 10.1172/JCI79300. Epub 2015 Mar 30. PMID 25822020

Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration.

 

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