Human FGF-21

Fibroblast growth factor 21 (FGF-21) is an endocrine hormone that regulates energy homeostasis and exerts cardioprotective functions during heart injury. FGF-21 is expressed in the liver, pancreas, heart, and adipose tissues. FGF-21 signaling is activated through the FGFR1c receptor and β-Klotho co-receptor. FGF-21 is an important regulator of glucose uptake and reduces cell apoptosis under stress conditions.

SKU Select size Price Buy
100-148-5ug Mini: 5 ug $63.00 + -
100-148-20ug Std.: 20 ug $158.00 + -
100-148-100ug Value: 100 ug $394.00 + -
100-148-500ug Midgi: 500 ug $1,701.00 + -
100-148-1mg Mg: 1 mg $2,835.00 + -
100-148AF-5ug Animal-Free Mini: 5 ug $69.00 + -
100-148AF-20ug Animal-Free Std.: 20 ug $174.00 + -
100-148AF-100ug Animal-Free Value: 100 ug $436.00 + -
100-148AF-500ug Animal-Free Midgi: 500 ug $1,869.00 + -
100-148AF-1mg Animal-Free Mg: 1 mg $3,119.00 + -

Alternate Names:  FGFL               Accession Number: Q9NSA1
Description:  Fibroblast growth factor 21 (FGF-21) is an endocrine hormone that regulates energy homeostasis and exerts cardioprotective functions during heart injury. FGF-21 is expressed in the liver, pancreas, heart, and adipose tissues. FGF-21 signaling is activated through the FGFR1c receptor and β-Klotho co-receptor. FGF-21 is an important regulator of glucose uptake and reduces cell apoptosis under stress conditions.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 19.5 kDa (182 aa)
AA Sequence:  MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELLLEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 100 mM sodium chloride, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

3T3 proliferation with β-klotho and heparin

ED50 ≤ 500 ng/mL (≥ 2.0 x 10^3 unit/mg) 

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0608 Lot 1117
SDS Lot 1117  
PDS Animal-Free Lot 1117 Animal-Free  
SDS Animal-Free     

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