Human EG-VEGF

Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is an angiogenic growth factor that is expressed in the ovaries, testis, adrenal, and placental tissues. EG-VEGF has mitogenic, chemoattractive, and antiapoptotic functional roles. EG-VEGF signaling is mediated through binding the G protein-coupled receptors prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2). Polycystic ovaries display strong EG-VEGF expression that is associated with increased angiogenesis and cyst formation, which could lead to the formation of polycystic ovary syndrome and infertility.

SKU Select size Price Buy
100-07-5ug Mini: 5 ug $63.00 + -
100-07-20ug Std.: 20 ug $158.00 + -
100-07-100ug Value: 100 ug $394.00 + -
100-07-500ug Midgi: 500 ug $1,701.00 + -
100-07-1mg Mg: 1 mg $2,835.00 + -
100-07AF-5ug Animal-Free Mini: 5 ug $69.00 + -
100-07AF-20ug Animal-Free Std.: 20 ug $174.00 + -
100-07AF-100ug Animal-Free Value: 100 ug $436.00 + -
100-07AF-500ug Animal-Free Midgi: 500 ug $1,869.00 + -
100-07AF-1mg Animal-Free Mg: 1 mg $3,119.00 + -

Alternate Names:  Prokineticin 1, PROK1               Accession Number: P58294
Description:  Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is an angiogenic growth factor that is expressed in the ovaries, testis, adrenal, and placental tissues. EG-VEGF has mitogenic, chemoattractive, and antiapoptotic functional roles. EG-VEGF signaling is mediated through binding the G protein-coupled receptors prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2). Polycystic ovaries display strong EG-VEGF expression that is associated with increased angiogenesis and cyst formation, which could lead to the formation of polycystic ovary syndrome and infertility.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 9.7 kDa (86 aa)
AA Sequence:  AVITGACERD VQCGAGTCCA ISLWLRGLRM CTPLGREGEE CHPGSHKVPF FRKRKHHTCP CLPNLLCSRF PDGRYRCSMD LKNINF
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

No biological activity data is available at this time

No biological activity data is available at this time

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions: Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX.  For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C, and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

 

To receive more information or for a bulk quote, email quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0618 Lot 0618
SDS Lot 1017 Lot 1017
PDS Animal-Free Lot 0909  
SDS Animal-Free Lot 0618 Animal-Free  
  Lot 1017 Animal-Free  
Papers that use this product:
 
 
 
 
 2014 Dec;21 Suppl 4:S665-71. doi: 10.1245/s10434-014-3765-8. Epub 2014 May 17. PMID 24838366

Anti-prokineticin1 (PROK1) monoclonal antibody suppresses angiogenesis and tumor growth in colorectal cancer.


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