Human CD40 Ligand Gel
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Human CD40-Ligand

Animal-Free (AF) proteins are identical to regular proteins and include additional documentation that they were produced using ANIMAL-FREE PROCESSES and contain only ANIMAL-FREE RAW MATERIALS.  Learn more HERE.

SKU Select a Size Price Buy
100-25-10ug Mini: 10 ug $63.00 + -
100-25-50ug Std.: 50 ug $158.00 + -
100-25-100ug Value: 100 ug $284.00 + -
100-25-500ug Midgi: 500 ug $725.00 + -
100-25-1mg Mg: 1 mg $1260.00 + -
100-25AF-10ug Animal-Free Mini: 10 ug $69.00 + -
100-25AF-50ug Animal-Free Std.: 50 ug $174.00 + -
100-25AF-100ug Animal-Free Value: 100 ug $310.00 + -
100-25AF-500ug Animal-Free Midgi: 500 ug $798.00 + -
100-25AF-1mg Animal-Free Mg: 1 mg $1386.00 + -
  • Weight
    0.0100 lbs
  • SKU
    100-25-10ug
Alternate Names:  TNFSF5, TRAP, CD154, gp39, T-BAM               Accession Number: P29965
Description:  CD40-Ligand, or CD154, is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells. CD40-Ligand binds and activates the CD40 receptor on antigen-presenting cells. CD40-Ligand stimulates B cell proliferation, immunoglobulin class switching, and antibody secretion. CD40-Ligand also induces cytokine production and tumoricidal activity in peripheral blood monocytes. CD40-Ligand is a co-stimulator of activated T cell proliferation and inflammatory protein production.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 16.3 kDa (149 aa)
AA Sequence:  MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity
Activity of HEK-BlueTM CD40L cells
 ED50 ≤ 50 ng/mL ; ≥ 2.0 x 10^4 units/mg
 

In addition to the acceptance criteria, this product has been tested with the following assay: (1)  IL-8 production by human PBMCs detected via ELISA

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or a quote, complete our bulk/custom order form.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0811 Lot 0213
SDS Lot 0412 Lot 0315
PDS Animal-Free Lot 0315  
SDS Animal-Free  Lot 0213  
  Lot 0315 Animal-Free  
  Lot 0213 Animal-Free  

 

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