Human BAFF

B cell-activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a type II member of the tumor necrosis factor (TNF) superfamily. BAFF is expressed as a transmembrane protein on T cells, macrophages, and dendritic cells. The transmembrane domain of BAFF can also be cleaved to produce a soluble protein fragment. BAFF binds to the TNF receptors known as B cell maturation antigen (BCMA), transmembrane activator and CAML interactor (TACI), and BAFF receptor (BAFFR). BAFF is important for the survival and maturation of peripheral B cells. Human BAFF shows activity on mouse splenocytes.

SKU Select size Price Buy
100-24-5ug Mini: 5 ug $63.00 + -
100-24-20ug Std: 20 ug $158.00 + -
100-24-100ug Value: 100 ug $609.00 + -
100-24-500ug Midgi: 500 ug $3,024.00 + -
100-24-1mg Mg: 1 $5,040.00 + -
100-24AF-5ug Animal-Free Mini: 5 ug $68.00 + -
100-24AF-20ug Animal-Free Std: 20 ug $173.00 + -
100-24AF-100ug Animal-Free Value: 100 ug $667.00 + -
100-24AF-500ug Animal-Free Midgi: 500 ug $3,329.00 + -
100-24AF-1mg Animal-Free Mg: 1 $5,544.00 + -

Alternate Names:  TALL, BLyS, THANK                Accession Number: Q9Y275
Description:  B cell-activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a type II member of the tumor necrosis factor (TNF) superfamily. BAFF is expressed as a transmembrane protein on T cells, macrophages, and dendritic cells. The transmembrane domain of BAFF can also be cleaved to produce a soluble protein fragment. BAFF binds to the TNF receptors known as B cell maturation antigen (BCMA), transmembrane activator and CAML interactor (TACI), and BAFF receptor (BAFFR). BAFF is important for the survival and maturation of peripheral B cells. Human BAFF shows activity on mouse splenocytes.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 18.5 kDa (163 aa)
AA Sequence:  MHHHHHHLVP RAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥90%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

No biological activity data is available at this time

No biological activity data is available at this time

 
Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 1111 Lot 1017
SDS Lot 1017  
PDS Animal-Free Lot 0112  
SDS Animal-Free  Lot 1017 Animal-Free