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Human IL-31

Interleukin 31 (IL-31) is an immunoregulatory cytokine that is expressed by activated type 2 T helper (Th2) cells.  IL-31 signals through a heterodimer receptor consisting of the IL-31 Receptor A (IL-31RA) and the oncostatin M receptor (OSMR), which are expressed on monocytes, epithelial cells, and keratinocytes.  IL-31 promotes allergic reactions and inflammatory skin diseases. 

SKU Select size Price Buy
100-204-5ug Mini: 5 ug $63.00 + -
100-204-25ug Std.: 25 ug $158.00 + -
100-204-100ug Value: 100 ug $788.00 + -
100-204-500ug Midgi: 500 ug $3,150.00 + -
100-204-1mg Mg: 1 mg $5,040.00 + -
100-204AF-5ug Animal-Free Mini: 5 ug $69.00 + -
100-204AF-25ug Animal-Free Std.: 25 ug $174.00 + -
100-204AF-100ug Animal-Free Value: 100 ug $867.00 + -
100-204AF-500ug Animal-Free Midgi: 500 ug $3,465.00 + -
100-204AF-1mg Animal-Free Mg: 1 mg $5,544.00 + -
Product Description
Alternate Names:  None                      Accession Number: Q6EBC2  
Description:  Interleukin 31 (IL-31) is an immunoregulatory cytokine that is expressed by activated type 2 T helper (Th2) cells.  IL-31 signals through a heterodimer receptor consisting of the IL-31 Receptor A (IL-31RA) and the oncostatin M receptor (OSMR), which are expressed on monocytes, epithelial cells, and keratinocytes.  IL-31 promotes allergic reactions and inflammatory skin diseases. 
Source:  Genetically modified E.coli cells. 
Predicted MW:  Monomer, 15.8 kDa (with 141 amino acids)
AA Sequence:  SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 20 mM sodium phosphate, 50 mM sodium chloride, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each production lot on its corresponding COA. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS-PAGE

≥95%

Endotoxin

Kinetic LAL (50% confidence)

≤1 EUs/µg

Biological Activity

STAT3 Activation in U-87 MG cells

Detectable at ≤ 25 ng/mL

 
Preparation and Storage
Country of Origin:  USA        
Shipping: 
Room temperature              
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL    
Instructions:  Centrifuge vial before opening.  Suspend the product by gently pipetting the above recommended solution down the sides of the vial.  DO NOT VORTEX.  Allow several minutes for complete reconstitution.  For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C, and avoid repeat freeze thaws.   
 
Expiration Date:                      

12 months from date of receipt when stored at -20°C to-80°C as supplied. 

1 month when stored at 4°C after reconstituting as directed.

3 months when stored at -20°C to -80°C after reconstituting as directed.

                                                                                   

THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS!           

 

To receive more information or a bulk quote, email us at quotes@shenandoah-bt.com.

  

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0517 Lot 0517
SDS Lot 0517 Animal-Free  
PDS Animal-Free    
SDS Animal-Free    

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