Human / Mouse / Rat GDF-11 (BMP-11)

Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling.

SKU Select size Price Buy
800-04-5UG Mini: 5 ug $63.00 + -
800-04-20UG Std.: 20 ug $158.00 + -
800-04-100UG Value: 100 ug $447.00 + -
800-04-500UG Midgi: 500 ug $2,205.00 + -
800-04-1MG Mg: 1 mg $3,675.00 + -
800-04AF-5UG Animal-Free Mini: 5 ug $69.00 + -
800-04AF-20UG Animal-Free Std.: 20 ug $174.00 + -
800-04AF-100UG Animal-Free Value: 100 ug $489.00 + -
800-04AF-500UG Animal-Free Midgi: 500 ug $2,426.00 + -
800-04AF-1MG Animal-Free Mg: 1 mg $4,043.00 + -

Catalog Number: 800-04 is a replacement for 100-57

Alternate Names:  BMP-11               Accession Number: O95390
Description:  Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy.
Source:  Genetically modified E.coli.
Predicted MW: Dimer, 12.5/24.9 kDa (109/218 aa)
AA Sequence:  NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

Alkaline phosphatase activity in ATDC5 cells

≤100 ng/mL

Preparation and Storage

Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile 10 mM HCl at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0915 Lot 0417
SDS Lot 0614 Lot 0616
PDS Animal-Free Lot 0417  
SDS Animal-Free Lot 0915 Animal-Free   
  Lot 0614 Animal-Free   
  Lot 0417 Animal-Free  

 

 

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