Chemokines

Shenandoah Chemokines Will Make Your Cells,
"MOVE IT, MOVE IT!" 

Chemotaxis of mammalian cells is important for a variety of functions related to:

- development (ex. fertilization of the egg)
- immunology (ex. lymphocyte recruitment)
- disease (ex. cancer metastasis)

The process of chemotaxis is initiated by a ligand/receptor interaction in which the signaling pathway activated by the receptor polarizes the cell to sense and move in the direction of increased ligand concentrations. Ligands that share a conserved three dimensional shape, characterized by disulfide bonds between cysteines, are called chemokines. The chemokine family activates signaling (thus, chemotaxis) through a group of receptors known as G-protein coupled receptors (GPCRs).

Shenandoah chemokines are rigorously tested for activity in migration assays using Boyden chambers and primary blood cells (PBMCs, purified T cells, etc) or cell lines (THP-1, Jurkat, etc).

Items: 11 of 1, per page
Product name Mini Standard Value Midgi Milligram
Human NAP-2 / CXCL7 Mini: 5 ug
  • $60.00
Std.: 20 ug
  • $150.00
Value: 100 ug
  • $400.00
Midgi: 500 ug
  • $1620.00
Mg: 1 mg
  • $2700.00