Bone Remodeling Research


Bone Basics 
A balance between RESORPTION and FORMATION. ​

Essentially, bone health is a delicate balance between the processes of constructing (formation) and deconstructing (resorption) bone. When there is an imbalance or disruption in the homeostasis of these processes, disease arises. Bone Resorption: Osteoclasts are large multinucleated cells that function to break down existing bone to release the Ca2+ and other materials that constitute the structure of the bone. Osteoclast precursor cells are derived from the hematopoietic lineage (specifically macrophages) and are differentiated and activated by M-CSF and soluble RANK Ligand (also exists in a cell bound format where it is also known as TRANCE). Inflammatory cytokines including TNF-alpha, IL-1 beta, IL-6 and IL-17 can promote the production of RANK Ligand, thus increase osteoclast differentiation and bone resorption. The activity of soluble RANK Ligand is inhibited by osteoprotegerin (OPG), which acts as a decoy receptor for RANK Ligand. Bone Formation: Osteoblasts are cells that function to build new bone in the process of bone formation. These cells move into the resorptive pit and deposit an organic matrix, called ostiod, which acts as a scaffold for calcium and phosphate to crystalize. BMPs, TGF-betas, IGFs, EGFs, FGFs, PDGFs, VEGFs and WNT proteins are all known to promote osteoblast differentiation and/or proliferation from mesenchymal stem cell (MSC) progenitors. WNT signaling can be inhibited by DKK1. Once the job of filling in the resorptive pit is complete, osteoblasts either undergo apoptosis, revert back to lining cells on the bone surface or become integrated into the bone material as osteocytes.

Items: 123 of 23, per page
Product name Mini Standard Value Midgi Milligram
Human / Mouse /Rat BMP-2 Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $485.00
Midgi: 500 ug
  • $2280.00
Mg: 1 mg
  • $3800.00
Human / Mouse Indian Hedgehog Mini: 5 ug
  • $60.00
Std.: 25 ug
  • $150.00
Value: 100 ug
  • $375.00
Midgi: 500 ug
  • $1500.00
Mg: 1 mg
  • $2500.00
Human / Mouse TGF-beta 3 Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $585.00
Midgi: 500 ug
  • $2880.00
Mg: 1 mg
  • $4800.00
Human EGF Mini: 100 ug
  • $60.00
Std.: 500 ug
  • $150.00
Value: 1 mg
  • $220.00
Mg: 5 mg
  • $1000.00
Animal-Free Mini: 100 ug
  • $65.00
Human IGF-I Mini: 20 ug
  • $60.00
Std.: 100 ug
  • $150.00
Value: 1 mg
  • $250.00
Mg: 5 mg
  • $1125.00
Animal-Free Mini: 20 ug
  • $65.00
Human IGF-II Mini: 10 ug
  • $60.00
Std.: 50 ug
  • $150.00
Value: 100 ug
  • $270.00
Midgi: 500 ug
  • $630.00
Mg: 1 mg
  • $1100.00
Human PDGF-AA Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $425.00
Midgi: 500 ug
  • $2100.00
Mg: 1 mg
  • $3500.00
Human PDGF-AB Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $425.00
Midgi: 500 ug
  • $2100.00
Mg: 1 mg
  • $3500.00
Human PDGF-BB Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $425.00
Midgi: 500 ug
  • $2100.00
Mg: 1 mg
  • $3500.00
Human RANK Ligand Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $580.00
Midgi: 500 ug
  • $2880.00
Mg: 1 mg
  • $4800.00
Human TGF beta 1 Mini: 5 ug
  • $75.00
Std: 20 ug
  • $270.00
Value: 100 ug
  • $995.00
Midgi: 500 ug
  • $2995.00
Mg: 1 mg
  • $4995.00
Human VEGF-121 Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $435.00
Midgi: 500 ug
  • $2160.00
Mg: 1 mg
  • $3600.00
Human VEGF-165 Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $435.00
Midgi: 500 ug
  • $2160.00
Mg: 1 mg
  • $3600.00
Mouse EGF Mini: 100 ug
  • $60.00
Std.: 500 ug
  • $150.00
Value: 1 mg
  • $220.00
Mg: 5 mg
  • $1000.00
Animal-Free Mini: 100 ug
  • $65.00
Mouse IGF-I Mini: 10 ug
  • $60.00
Std.: 50 ug
  • $150.00
Value: 100 ug
  • $270.00
Midgi: 500 ug
  • $690.00
Mg: 1 mg
  • $1200.00
Mouse PDGF-AA Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $425.00
Midgi: 500 ug
  • $2100.00
Mg: 1
  • $3500.00
Mouse PDGF-BB Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $425.00
Midgi: 500 ug
  • $2100.00
Mg: 1
  • $3500.00
Mouse RANK Ligand Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $580.00
Midgi: 500 ug
  • $2880.00
Mg: 1 mg
  • $4800.00
Mouse VEGF-120 Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $435.00
Midgi: 500 ug
  • $2160.00
Mg: 1
  • $3600.00
Mouse VEGF-165 Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $435.00
Midgi: 500 ug
  • $2160.00
Mg: 1
  • $3600.00
Rat EGF Mini: 20 ug
  • $60.00
Std.: 100 ug
  • $150.00
Value: 250 ug
  • $310.00
Midgi: 500 ug
  • $515.00
Mg: 1
  • $900.00
Rat IGF-I Mini: 10 ug
  • $60.00
Std.: 50 ug
  • $150.00
Value: 100 ug
  • $270.00
Midgi: 500 ug
  • $690.00
Mg: 1 mg
  • $1200.00
Rat VEGF-165 Mini: 2 ug
  • $60.00
Std.: 10 ug
  • $150.00
Value: 100 ug
  • $435.00
Midgi: 500 ug
  • $2160.00
Mg: 1
  • $3600.00