Previous image Next image
Zoom image

Mouse IL-17A

Animal-Free (AF) proteins are identical to regular proteins and include additional documentation showing that they were produced with no materials of animal or human origin using ANIMAL-FREE purification processes.  Learn more HERE.

SKU Select size Price Buy
200-59-5ug Mini: 5 ug $60.00  
200-59-25ug Std.: 25 ug $150.00  
200-59-100ug Value: 100 ug $375.00  
200-59-500ug Midgi: 500 ug $1620.00  
200-59-1mg Mg: 1 mg $2700.00  
200-59AF-5ug Animal-Free Mini: 5 ug $65.00  
200-59AF-25ug Animal-Free Std.: 25 ug $165.00  
200-59AF-100ug Animal-Free Value: 100 ug $415.00  
200-59AF-500ug Animal-Free Midgi: 500 ug $1780.00  
200-59AF-1mg Animal-Free Mg: 1 mg $2970.00  
View the available lots and COAs for this product HERE

Catalog Number: 200-59

Alternate Names:  IL-17, CTLA-8               Accession Number: Q62386
Description:  Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins.  IL-17A is a proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes.  IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion.  In turn, the cytokines and chemokines mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites.  Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis.  Human, mouse, and rat IL-17A show activity on mouse cells.  
Source:  Genetically modified E.coli.
Predicted MW: Dimer, 15.1/30.2 kDa (134/268 aa)
AA Sequence:  MAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

Production of IL-6 by mouse 3T3 cells

≤5 ng/mL; ≥ 2.0 x 10^5 units/mg

 

 

 Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature              Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

Data Sheet (PDF)

SDS Document (PDF)

Animal-Free Documents:

Data Sheet AF (PDF)

SDS Document AF (PDF)

Papers that use this product (PMID):
23850622
 

To receive more information or a quote, complete our bulk/custom order form.

  • Select size
    Mini: 5 ug, Std.: 25 ug, Value: 100 ug, Midgi: 500 ug, Mg: 1 mg, Animal-Free Mini: 5 ug, Animal-Free Std.: 25 ug, Animal-Free Value: 100 ug, Animal-Free Midgi: 500 ug, Animal-Free Mg: 1 mg