Human / Mouse Indian Hedgehog

Indian hedgehog (IHH) is an essential signaling factor that is secreted in the gut, cartilage, and bone during embryonic development. IHH acts through the patched (PTC) receptor to induce transcriptional changes important for bone and cartilage development. IHH also induces the expression of parathyroid hormone-related peptide (PTHrP), which in turn mediates IHH activity during chondrocyte differentiation, forming a negative feedback loop.

SKU Select size Price Buy
800-05-5UG Mini: 5 ug $63.00 + -
800-05-25UG Std.: 25 ug $158.00 + -
800-05-100UG Value: 100 ug $394.00 + -
800-05-500UG Midgi: 500 ug $1,575.00 + -
800-05-1MG Mg: 1 mg $2,625.00 + -
800-05AF-5UG Animal-Free Mini: 5 ug $69.00 + -
800-05AF-25UG Animal-Free Std.: 25 ug $174.00 + -
800-05AF-100UG Animal-Free Value: 100 ug $436.00 + -
800-05AF-500UG Animal-Free Midgi: 500 ug $1,733.00 + -
800-05AF-1MG Animal-Free Mg: 1 mg $2,888.00 + -

Catalog Number: 800-05 is a replacement for Human 100-182 / mouse 200-73 (100% sequence identity)

Alternate Names:  HHG-2               Accession Number: Q14623
Description:  Indian hedgehog (IHH) is an essential signaling factor that is secreted in the gut, cartilage, and bone during embryonic development. IHH acts through the patched (PTC) receptor to induce transcriptional changes important for bone and cartilage development. IHH also induces the expression of parathyroid hormone-related peptide (PTHrP), which in turn mediates IHH activity during chondrocyte differentiation, forming a negative feedback loop.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 19.9 kDa (177 aa)
AA Sequence:  MIIGPGRVVG SRRRPPRKLV PLAYKQFSPN VPEKTLGASG RYEGKIARSS ERFKELTPNY NPDIIFKDEE NTGADRLMTQRCKDRLNSLA ISVMNQWPGV KLRVTEGWDE DGHHSEESLH YEGRAVDITT SDRDRNKYGL LARLAVEAGF DWVYYESKAH VHCSVKSEHSAAAKTGG
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

No biological activity data is available at this time

No biological activity data is available at this time 

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  10 mM HCl at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

 

Product Datasheets Certificates of Analysis Certificates of Origin
PDS Lot 0914 Lot 0914
SDS Lot 0914 Animal-Free  
PDS Animal-Free    
SDS Animal-Free    

 

 

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