Recombinant Proteins
Human Fractalkine
Catalog # 100-174
Fractalkine, also known as CX3CL1, is an atypical chemokine that was the first of a fourth chemokine motif (CX3C). It is thought to function as a T cell and monocyte chemotractant and is produced by non-haemopoietic cells. Fractalkine is made in a soluble and membrane bound form in activated endothelial cells which is thought to promote adhesion of leukocytes. Recombinant human Fractalkine is a non-glycosylated protein, containing 76 amino acids, with a molecular weight of 8.6 kDa.
Protein Bundles
Monocyte/DC Protein Bundle (GM-CSF/IL-4)
100 ug of each: IL-4 and GM-CSF
Catalog # Human PB-500-01 or Mouse PB-500-02
Dendrictic cells are an important type of immune cell that function to activate T and B cells via their role as an antigen presenting cells. Monocytes isolated from peripheral blood can be differentiated to immature dendritic cells (iDCs) through culturing in the presence of interleukin 4 (IL-4) and granulocyte-macrophage colony stimulating factor (GM-CSF) for 5-7 days. The characteristics of monocyte-derived iDCs are detectable after 2 days of culture with IL-4/GM-CSF and include: the down regulation of CD14 surface expression, an increase in dextran uptake and an increased response to MIP-1α. Subsequent culturing with pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6) can further differentiate the iDCs into mature dendritic cells (mDCs) that have full T cell stimulating capacity.
Monoclonal Antibodies
Mouse IL-27/p28 (Clone 3H12), Rat IgG2a/k
Catalog # MAB-200-P28
AND
Mouse IL-27/p28 (Clone 3H12), Rat IgG2a/k- Biotin Conjugate
Catalog # MAB-200-P28BIO
The p28 subunit of IL-27 (IL-27/p28), also known as Interleukin-30 (IL-30), is a member of the IL-12 family of cytokines. When combined with EBI3 (Epstein-Barr virus induced gene 3), p28 forms a heterodimer known as IL-27. p28 is thought to be a pro-inflammatory cytokine inducing immuno-modulatory effects, but the details of these effects are currently unclear and research is focused on delineating its specific biological functions.
Mouse IL-17A (Clone20B4), Rat IgG2a/k
Catalog # MAB-200-IL17A
AND
Mouse IL-17A (Clone 20B4), Rat IgG2a/k- Biotin Conjugate
Catalog # MAB-200-IL17ABIO
Interleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F). IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most importantly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. Human, mouse and rat IL-17A show activity on mouse cells.
Human IL-6 (Clone33A12), Mouse IgG1/k
Catalog #MAB-100-IL6
AND
Human IL-6 (Clone 33A12), Mouse IgG1/k -Biotin Conjugate
Catalog # MAB-100-IL6BIO
Interleukin 6 (IL-6) is an important pro-inflammatory and anti-inflammatory cytokine expressed by T cells, macrophages and muscle cells. IL-6 signals through a receptor complex containing two receptors, IL-6Rα and gp130. IL-6 has an important function in promoting fever and can serve to stimulate an immune response to trauma. IL-6 is often used for growth of hybridoma cell lines. Human IL-6 is active on mouse and rat cells.
